Bone density increase by high doses of vitamin d3 pdf

Bone density increase by high doses of vitamin d3 pdf
4/09/2017 · Getting enough vitamin C in your diet can increase your bone mineral density, especially if you’re a postmenopausal woman. [23] [24] Adult men should get at least 90mg of vitamin C per day, and adult women should get at least 75mg per day.
In fact, data from studies36, 37 comparing high-dose with low-dose vitamin D supplements suggest that individuals on a low dose have improved bone mineral density, although differences between the groups were not significant.
Printer Friendly PDF this page! Follow this page for updates. Links to this page. Bone diseases related to many Vitamin D diseases – June 2016 Bones not helped much by vitamin D (low dose or short term) National Osteoporosis Foundation – Feb 2016 Health Problems and D Highlights of Vitamin D Wiki
This suggests that dietary vitamin D 3 supplementation may increase bone health by improving bone material strength and supports the use of vitamin D 3 supplementation, during adolescence, for achieving a higher peak bone mass in adulthood and thereby preventing osteoporosis.
In a previous study , we investigated bone density and bone metabolism in children affected by DMD, with or without steroid treatment, and observed decreased bone density, increased bone turnover and low serum 25-OH vitamin D (25-OH D) levels, particularly in children taking GCs.
Vitamin D3 supplementation is associated with increased bone density, and studies that combine vitamin D with calcium have produced considerably better results than either nutrient alone. Most experts recommend daily doses of at least 2,000 IU of D3.
Effect of High-Dose Vitamin D3 Intake on Ambulation, Muscular Pain and Bone Mineral Density in a Woman with Multiple Sclerosis: A 10-Year Longitudinal Case Report Barbara M. van Amerongen 1,2,* and François Feron 3 1 Department of Molecular Cell Biology and Immunology, VU University Medical Center, 1017 MB Amsterdam, The Netherlands 2 Department of Cariology Endodontology …

Vitamin D3 Supplementation Increases Spine Bone Mineral

Higher doses of vitamin D may boost preemies’ bone health
Calcium and High-dose Vitamin D Supplementation on Bone Mineral Density Among HIV-infected Children and Adolescents (CAL-D) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
The effects of vitamin D on fractures, falls, and bone mineral density are uncertain, particularly for high vitamin D doses. We aimed to determine the effect of vitamin D supplementation on fractures, falls, and bone density.
Deficiency of vitamin D3 causes metabolic bone diseases living and non-living things via the process of Biofield like osteomalacia and exacerbate osteoporosis, etc. [5]. The Energy Healing.
If this reflects a causal relation, vitamin D given in high doses may have a negative effect on bone. Given the focus on the need for higher doses of vitamin D [ 15 ] this is an important issue to settle, but so far, most intervention studies have used vitamin D in doses of 800 IU per day or less [ 13 ].
This suggests that dietary vitamin D3 supplementation may increase bone health by improving bone material strength and supports the use of vitamin D3 supplementation, during adolescence, for
The study authors said they also found that doubling the typical dose of Vitamin D from 400 to 800 IUs could reduce the number of premature infants with extremely low bone density.
One of the actions of vitamin D3 is to increase the amount of calcium that the intestines take up, which means that it may be useful for combating low calcium levels as well. Indeed, low blood calcium is often treated with vitamin D3.

Those high doses of vitamin D stimulate both osteoblastic and osteoclastic activities simultaneously as demonstrated by measuring P1NP and CTX respectively. Aerobic exercise (initiated after the second medical appointment) will induce production of calcitonin and efficiently inhibit osteoclastic activity.
ORIGINAL ARTICLE The effect of high-dose vitamin D3 supplementation on bone mineral density in subjects with prediabetes A. U. Larsen1 & G. Grimnes1,2 & R. Jorde1,2
Some studies of vitamin D effects on falling have utilised data in which high doses of vitamin were used, often in women without evidence of vitamin D insufficiency. Careful consideration of these studies and dose ranging studies indicate that high monthly or yearly vitamin D doses may increase falls risk especially in elderly women 20,21 22. An epidemiological study has also reported an
Notably, recent studies have demonstrated that high vitamin D levels (above the physiological requirements) can exert a deleterious effects on bone health [2],[3]. Furthermore, it has been shown that high-levels of vitamin D can lead to impaired muscle function [4] and increase the risk of falling [5] – both important fracture risk factors. These findings are in line with previous RCTs showing
To examine the effectiveness of high-dose vitamin D supplementation to increase trabecular and cortical bone mineral density at the radius. 3. To examine whether high-dose vitamin D supplementation has an effect on physiological determinants of bone mass (parathyroid hormone, activity of bone metabolism, muscle function).
7/01/2010 · 1. Nutr J. 2010 Jan 7;9:1. doi: 10.1186/1475-2891-9-1. No significant effect on bone mineral density by high doses of vitamin D3 given to overweight subjects for one year.

They received either 500 mg of calcium plus 700 IU of vitamin D3 (cholecalciferol) per day or placebo. Bone mineral density was measured by dual-energy x-ray absorptiometry, blood and urine were
Conclusions: Supplementation with high doses of vitamin D for one year does not appear to have a negative effect on BMD in healthy subjects. In order to disclose a positive effect, subjects with low BMD and/or low serum 25(OH)D levels need to be studied.
The optimal dose of vitamin D to optimize bone metabolism in the elderly is unclear. We tested the hypothesis that vitamin D, at a dose higher than recommended by the Institute of Medicine (IOM), has a beneficial effect on bone remodeling and mass.
Results from a recent randomized controlled trial on vitamin D3 supplementation suggest that even modestly high doses of vitamin D3, when given once monthly, might …
Journal of Osteoporosis Hindawi Publishing Corporation
This suggests that dietary vitamin D3 supplementation may increase bone health by improving bone material strength and supports the use of vitamin D 3 supplementation, during adolescence, for achieving a higher peak bone mass in adulthood and thereby preventing osteoporosis.
“Giving pensioners high doses of vitamin D to strengthen their leg bones may put them at higher risk of a fall,” The Times reports after a Swiss study suggested high doses of the supplement offer no benefits, but do increase the risk of falling.
influence on bone than vitamin K1, and should be considered for prevention or treatment in those conditions known to contribute to osteoporosis. (Altern Med Rev 2005;10(1):24-35) Introduction Vitamin K2 exerts a powerful influence on bone building, especially in osteoporosis, and has been cited as one of the most frequently prescribed treatments for osteoporosis in Japan.1 The ability to
Some people with low bone density do not need any osteoporosis medication whereas others with low bone density are at high risk for fractures and should be started on medication.
Insufficient Vitamin K2 (and Vitamin D) intake can lead to decreased bone mineral density because osteocalcin is not activated, and thus, Calcium is not directed into the formation of new bone. Not only would this contribute to osteopenia or osteoporosis, but bone fractures and other skeletal issues are more likely to occur.
Background. Vitamin D is important for bone health, although high loading doses have been associated with an increase in fracture risk. The mechanisms remain uncertain. Aim. We hypothesize that supraphysiological concentrations of 1,25 (OH)2 vitamin D may inhibit formation by increasing the production of Wnt inhibitors: sclerostin and DKK1. – road rules handbook nt Dawson-Hughes B: Positive association between 25-hydroxy vitamin D levels and bone mineral density: a population-based study of younger and older adults. (2004). Effects of oral contraceptives on circulating osteoprotegerin and soluble RANK ligand serum levels in healthy young women.
Furthermore, it has been shown that high-levels of vitamin D can lead to impaired muscle function [4] and increase the risk of falling [5] – both important fracture risk factors. These findings are in line with previous RCTs showing more falling and increased fracture risk in individuals randomized to high-dose vitamin D [2],[3].
Many clinical trials have demonstrated that vitamin D supports bone strength and density.* Supplementation with vitamin D at doses over 700 IU daily has been associated with a 23-26% improvement in bone health,* 16 although these benefits appear to be primarily for older adults. 17
In meta-analyses supplementation with vitamin D appears to reduce incidence of fractures, and in cross-sectional studies there is a positive association between serum 25-hydroxyvitamin D (25(OH)D) levels and bone mineral density (BMD). However, the effect of supplementation with high doses of
Vitamin D3 is needed to increase absorption of calcium from the intestine to make it available for bone building. However, it’s the third leg of the stool — vitamin K2 — that ensures that the calcium in the bloodstream reaches bone and is incorporated into the bone matrix.
Background. In meta-analyses supplementation with vitamin D appears to reduce incidence of fractures, and in cross-sectional studies there is a positive association between serum 25-hydroxyvitamin D (25(OH)D) levels and bone mineral density (BMD).
If you have low bone density get your blood level checked every 6 months to find the dose of vitamin D 3 that keeps you in the optimal levels. Vitamin K2 This vitamin takes the calcium that vitamin D has dumped into deposits in the bone, and integrates it or weaves it into the bone structure.
received placebo or high-dose vitamin D3 (a loading dose of 540,000 IU and starting 1 month after the loading dose five monthly maintenance doses of 90,000 IU).
17/04/2014 · The use of moderate doses of vitamin D (800 IU/day) appears to be more effective in the reduction of bone turnover and increased BMD compared to high doses (6500 IU/day) . However, in obese subjects, the 7000 IU/day dose of this vitamin was effective in reducing bone turnover and increasing BMD [ 45 ].
If a blood test shows very low vitamin D levels, and you are also getting bone pain as a result then higher doses may be prescribed to rapidly improve your vitamin D levels. You may be given a total of approximately 300,000 IU vitamin D, either as weekly or daily doses over 6 to 10 weeks, before you go down to the lower dose taken long term (usually 800IU).
We hypothesized that an “adolescent-friendly” monthly dose of vitamin D3 (50000 IU ) would increase BMD and decrease PTH more effectively than a daily multivitamin containing vitamin D3 (400 IU) and calcium in youth with HIV being chronically treated with TDF-containing cART, independent of baseline vitamin D status.
Participants who had received the monthly high dose of vitamin D3 had gained an average bone mineral density of 1.15 percent, compared to an average increase of .09 percent in the placebo group. For participants in the high dose vitamin D3 group, improvement in bone density occurred regardless of whether they had a deficiency of the vitamin when they enrolled in the study.
Vitamin D Boosts Bone Density, contrary to headlines Vitamin D as a supplement for bone density is currently under attack. Whenever a supplement proves too effective, the pharmaceutical industry rallies to shoot it down, least it steal business from them.
Effect of High-Dose Vitamin D on Bone Density in
Many lines of evidence suggest that low calcium intake adversely affects bone mineral density. 1 Low calcium intake has been associated with lower bone density in some cross-sectional studies, 4–6 though not all. 7 Interventions to increase calcium intake in postmenopausal women have shown beneficial effects on bone density, 8–10 though in some studies the benefit was small and
bone material strength and supports the use of vitamin D 3 supplementation, during adolescence, for achieving a higher peak bone mass in adulthood and thereby preventing osteoporosis.
Introduction. Observational studies have shown accelerated bone loss in ICU survivors. A reversible contributor is vitamin D deficiency. In a post hoc analysis of the VITdAL-ICU study, we evaluated the effect of high-dose vitamin D3 on the bone turnover markers (BTM) …
High doses of vitamin D and calcium can cause problems, such as kidney stones. Limit intake of vitamin A, particularly in the form of retinol. Too much vitamin A can lower bone density.
Nutrition as Prevention and Treatment of Osteoporosis M High doses of vitamin D, while increasing absorption of calcium by 12-13 %, increase its renal excretion. High doses of vitamin D are therefore not recommended (Scholz-Ahrens and Schrezenmeier 2004, Grashoff 2002). Lactose increases intestinal absorption of calcium (Grashoff 2002). It is not exactly known why, but it may be because it
van Amerongen, B.M.; Feron, F. Effect of High-Dose Vitamin D3 Intake on Ambulation, Muscular Pain and Bone Mineral Density in a Woman with Multiple Sclerosis: A 10 …
A total of 452 participants were randomized to receive monthly doses of vitamin D3 100 000 IU, or placebo. The primary end-point was change in lumbar spine BMD. Exploratory analyses to identify thresholds of baseline 25-hydroxyvitamin D for vitamin D effects on BMD were prespecified.
Effect of vitamin D3 on bone turnover markers in critical

Impact of Calcium and Two Doses of Vitamin D on Bone
The optimal dose for bone strength and infection prevention in healthy infants remains unclear. Objective To determine whether daily supplementation with 1200 IU of vitamin D 3 increases bone strength or decreases incidence of infections in the first 2 …
L. M. Smith, J. C. Gallagher, M. Kaufmann and G. Jones, Effect of increasing doses of vitamin D on bone mineral density and serum N‐terminal telopeptide in elderly women: a randomized controlled trial, Journal of Internal Medicine, , (2018).
The role of calcium and vitamin D in bone health in the general population Bess Dawson-Hughes, M.D.
When high doses (prednisolone > 20 mg/day or equivalent) are used, the annual rate of loss of spinal bone density is 5-15%. The rate of bone loss is most marked in the first six months after starting corticosteroids and can be as high as 27%. Bone loss may slow irrespective of whether or not the dose is tapered as the patient’s underlying condition improves. The relationship of dose to
Vitamin D supplements and tests NOS UK Charity

Nutrition as Prevention and Treatment of Osteoporosis
No significant effect on bone mineral density by high doses of vitamin D3 given to overweight subjects for one year Article (PDF Available) in Nutrition Journal 9(1):1 · January 2010 with 34 Reads
Abstract. High doses of the active form of vitamin D 3, 1,25-dihydroxyvitamin D 3 [1,25(OH) 2 D 3], prevent diabetes in the NOD mouse but also elicit unwanted calcemic side effects.
15/01/2018 · Yet the doses of vitamin A used in the high-vitamin A and low-vitamin A groups were so disparate that it is impossible to compare equivalent vitamin A-to-vitamin D ratios between the two groups: the highest vitamin A-to-vitamin D ratio in the low-vitamin A group was 7.5, while the lowest vitamin A-to-vitamin D ratio in the high-vitamin A group was 14. For reference, high-vitamin cod …
25‐Hydroxyvitamin D Threshold for the Effects of Vitamin D
We investigated whether vitamin D supplementation aff ects bone mineral density. Methods We searched Web of Science, Embase, and the Cochrane Database, from inception to July 8, 2012, for trials assessing the eff ects of vitamin D (D3 or D2, but not vitamin D metabolites) on bone mineral density .
Higher vitamin D dosing decreases risk of premature infants having low bone density . Download PDF Copy; Oct 13 2017. Results of a University of Nebraska …

Calcium and High-dose Vitamin D Supplementation on Bone

Bone Appétit New Information on Calcium & Vitamin D
– Effects of vitamin D supplements on bone mineral density
(PDF) High dose dietary vitamin D3 increases bone mass and

Medium doses of Vitamin D Decrease Falls and Higher Doses

How to Increase Bone Density 13 Steps (with Pictures

High doses of vitamin D3 may decrease bone loss associated
Effect of Monthly High‐Dose Vitamin D on Bone Density in

Notably, recent studies have demonstrated that high vitamin D levels (above the physiological requirements) can exert a deleterious effects on bone health [2],[3]. Furthermore, it has been shown that high-levels of vitamin D can lead to impaired muscle function [4] and increase the risk of falling [5] – both important fracture risk factors. These findings are in line with previous RCTs showing
17/04/2014 · The use of moderate doses of vitamin D (800 IU/day) appears to be more effective in the reduction of bone turnover and increased BMD compared to high doses (6500 IU/day) . However, in obese subjects, the 7000 IU/day dose of this vitamin was effective in reducing bone turnover and increasing BMD [ 45 ].
Higher vitamin D dosing decreases risk of premature infants having low bone density . Download PDF Copy; Oct 13 2017. Results of a University of Nebraska …
Effect of High-Dose Vitamin D3 Intake on Ambulation, Muscular Pain and Bone Mineral Density in a Woman with Multiple Sclerosis: A 10-Year Longitudinal Case Report Barbara M. van Amerongen 1,2,* and François Feron 3 1 Department of Molecular Cell Biology and Immunology, VU University Medical Center, 1017 MB Amsterdam, The Netherlands 2 Department of Cariology Endodontology …
Introduction. Observational studies have shown accelerated bone loss in ICU survivors. A reversible contributor is vitamin D deficiency. In a post hoc analysis of the VITdAL-ICU study, we evaluated the effect of high-dose vitamin D3 on the bone turnover markers (BTM) …
Those high doses of vitamin D stimulate both osteoblastic and osteoclastic activities simultaneously as demonstrated by measuring P1NP and CTX respectively. Aerobic exercise (initiated after the second medical appointment) will induce production of calcitonin and efficiently inhibit osteoclastic activity.
Background. Vitamin D is important for bone health, although high loading doses have been associated with an increase in fracture risk. The mechanisms remain uncertain. Aim. We hypothesize that supraphysiological concentrations of 1,25 (OH)2 vitamin D may inhibit formation by increasing the production of Wnt inhibitors: sclerostin and DKK1.
This suggests that dietary vitamin D3 supplementation may increase bone health by improving bone material strength and supports the use of vitamin D3 supplementation, during adolescence, for
van Amerongen, B.M.; Feron, F. Effect of High-Dose Vitamin D3 Intake on Ambulation, Muscular Pain and Bone Mineral Density in a Woman with Multiple Sclerosis: A 10 …
Nutrition as Prevention and Treatment of Osteoporosis M High doses of vitamin D, while increasing absorption of calcium by 12-13 %, increase its renal excretion. High doses of vitamin D are therefore not recommended (Scholz-Ahrens and Schrezenmeier 2004, Grashoff 2002). Lactose increases intestinal absorption of calcium (Grashoff 2002). It is not exactly known why, but it may be because it
Abstract. High doses of the active form of vitamin D 3, 1,25-dihydroxyvitamin D 3 [1,25(OH) 2 D 3], prevent diabetes in the NOD mouse but also elicit unwanted calcemic side effects.
ORIGINAL ARTICLE The effect of high-dose vitamin D3 supplementation on bone mineral density in subjects with prediabetes A. U. Larsen1 & G. Grimnes1,2 & R. Jorde1,2
This suggests that dietary vitamin D3 supplementation may increase bone health by improving bone material strength and supports the use of vitamin D 3 supplementation, during adolescence, for achieving a higher peak bone mass in adulthood and thereby preventing osteoporosis.
L. M. Smith, J. C. Gallagher, M. Kaufmann and G. Jones, Effect of increasing doses of vitamin D on bone mineral density and serum N‐terminal telopeptide in elderly women: a randomized controlled trial, Journal of Internal Medicine, , (2018).
We investigated whether vitamin D supplementation aff ects bone mineral density. Methods We searched Web of Science, Embase, and the Cochrane Database, from inception to July 8, 2012, for trials assessing the eff ects of vitamin D (D3 or D2, but not vitamin D metabolites) on bone mineral density .

RE Vitamin D status and bone health a possible inverse
High dose dietary vitamin D3 increases bone mass and

This suggests that dietary vitamin D3 supplementation may increase bone health by improving bone material strength and supports the use of vitamin D3 supplementation, during adolescence, for
Abstract. High doses of the active form of vitamin D 3, 1,25-dihydroxyvitamin D 3 [1,25(OH) 2 D 3], prevent diabetes in the NOD mouse but also elicit unwanted calcemic side effects.
We hypothesized that an “adolescent-friendly” monthly dose of vitamin D3 (50000 IU ) would increase BMD and decrease PTH more effectively than a daily multivitamin containing vitamin D3 (400 IU) and calcium in youth with HIV being chronically treated with TDF-containing cART, independent of baseline vitamin D status.
To examine the effectiveness of high-dose vitamin D supplementation to increase trabecular and cortical bone mineral density at the radius. 3. To examine whether high-dose vitamin D supplementation has an effect on physiological determinants of bone mass (parathyroid hormone, activity of bone metabolism, muscle function).
In meta-analyses supplementation with vitamin D appears to reduce incidence of fractures, and in cross-sectional studies there is a positive association between serum 25-hydroxyvitamin D (25(OH)D) levels and bone mineral density (BMD). However, the effect of supplementation with high doses of
Vitamin D Boosts Bone Density, contrary to headlines Vitamin D as a supplement for bone density is currently under attack. Whenever a supplement proves too effective, the pharmaceutical industry rallies to shoot it down, least it steal business from them.
If this reflects a causal relation, vitamin D given in high doses may have a negative effect on bone. Given the focus on the need for higher doses of vitamin D [ 15 ] this is an important issue to settle, but so far, most intervention studies have used vitamin D in doses of 800 IU per day or less [ 13 ].
The effects of vitamin D on fractures, falls, and bone mineral density are uncertain, particularly for high vitamin D doses. We aimed to determine the effect of vitamin D supplementation on fractures, falls, and bone density.

Calcium and Vitamin D Necessary for Bone Health
Higher doses of vitamin D may boost preemies’ bone health

The role of calcium and vitamin D in bone health in the general population Bess Dawson-Hughes, M.D.
15/01/2018 · Yet the doses of vitamin A used in the high-vitamin A and low-vitamin A groups were so disparate that it is impossible to compare equivalent vitamin A-to-vitamin D ratios between the two groups: the highest vitamin A-to-vitamin D ratio in the low-vitamin A group was 7.5, while the lowest vitamin A-to-vitamin D ratio in the high-vitamin A group was 14. For reference, high-vitamin cod …
Introduction. Observational studies have shown accelerated bone loss in ICU survivors. A reversible contributor is vitamin D deficiency. In a post hoc analysis of the VITdAL-ICU study, we evaluated the effect of high-dose vitamin D3 on the bone turnover markers (BTM) …
influence on bone than vitamin K1, and should be considered for prevention or treatment in those conditions known to contribute to osteoporosis. (Altern Med Rev 2005;10(1):24-35) Introduction Vitamin K2 exerts a powerful influence on bone building, especially in osteoporosis, and has been cited as one of the most frequently prescribed treatments for osteoporosis in Japan.1 The ability to
Higher vitamin D dosing decreases risk of premature infants having low bone density . Download PDF Copy; Oct 13 2017. Results of a University of Nebraska …
Many clinical trials have demonstrated that vitamin D supports bone strength and density.* Supplementation with vitamin D at doses over 700 IU daily has been associated with a 23-26% improvement in bone health,* 16 although these benefits appear to be primarily for older adults. 17
If a blood test shows very low vitamin D levels, and you are also getting bone pain as a result then higher doses may be prescribed to rapidly improve your vitamin D levels. You may be given a total of approximately 300,000 IU vitamin D, either as weekly or daily doses over 6 to 10 weeks, before you go down to the lower dose taken long term (usually 800IU).
L. M. Smith, J. C. Gallagher, M. Kaufmann and G. Jones, Effect of increasing doses of vitamin D on bone mineral density and serum N‐terminal telopeptide in elderly women: a randomized controlled trial, Journal of Internal Medicine, , (2018).
We investigated whether vitamin D supplementation aff ects bone mineral density. Methods We searched Web of Science, Embase, and the Cochrane Database, from inception to July 8, 2012, for trials assessing the eff ects of vitamin D (D3 or D2, but not vitamin D metabolites) on bone mineral density .
van Amerongen, B.M.; Feron, F. Effect of High-Dose Vitamin D3 Intake on Ambulation, Muscular Pain and Bone Mineral Density in a Woman with Multiple Sclerosis: A 10 …
In meta-analyses supplementation with vitamin D appears to reduce incidence of fractures, and in cross-sectional studies there is a positive association between serum 25-hydroxyvitamin D (25(OH)D) levels and bone mineral density (BMD). However, the effect of supplementation with high doses of
This suggests that dietary vitamin D3 supplementation may increase bone health by improving bone material strength and supports the use of vitamin D 3 supplementation, during adolescence, for achieving a higher peak bone mass in adulthood and thereby preventing osteoporosis.
Many lines of evidence suggest that low calcium intake adversely affects bone mineral density. 1 Low calcium intake has been associated with lower bone density in some cross-sectional studies, 4–6 though not all. 7 Interventions to increase calcium intake in postmenopausal women have shown beneficial effects on bone density, 8–10 though in some studies the benefit was small and
Insufficient Vitamin K2 (and Vitamin D) intake can lead to decreased bone mineral density because osteocalcin is not activated, and thus, Calcium is not directed into the formation of new bone. Not only would this contribute to osteopenia or osteoporosis, but bone fractures and other skeletal issues are more likely to occur.
One of the actions of vitamin D3 is to increase the amount of calcium that the intestines take up, which means that it may be useful for combating low calcium levels as well. Indeed, low blood calcium is often treated with vitamin D3.

Effect of vitamin D3 on bone turnover markers in critical
Calcium Is The Key To Bone Strengthening! Wrong. Collagen Is.

influence on bone than vitamin K1, and should be considered for prevention or treatment in those conditions known to contribute to osteoporosis. (Altern Med Rev 2005;10(1):24-35) Introduction Vitamin K2 exerts a powerful influence on bone building, especially in osteoporosis, and has been cited as one of the most frequently prescribed treatments for osteoporosis in Japan.1 The ability to
received placebo or high-dose vitamin D3 (a loading dose of 540,000 IU and starting 1 month after the loading dose five monthly maintenance doses of 90,000 IU).
To examine the effectiveness of high-dose vitamin D supplementation to increase trabecular and cortical bone mineral density at the radius. 3. To examine whether high-dose vitamin D supplementation has an effect on physiological determinants of bone mass (parathyroid hormone, activity of bone metabolism, muscle function).
A total of 452 participants were randomized to receive monthly doses of vitamin D3 100 000 IU, or placebo. The primary end-point was change in lumbar spine BMD. Exploratory analyses to identify thresholds of baseline 25-hydroxyvitamin D for vitamin D effects on BMD were prespecified.
Vitamin D3 supplementation is associated with increased bone density, and studies that combine vitamin D with calcium have produced considerably better results than either nutrient alone. Most experts recommend daily doses of at least 2,000 IU of D3.
Notably, recent studies have demonstrated that high vitamin D levels (above the physiological requirements) can exert a deleterious effects on bone health [2],[3]. Furthermore, it has been shown that high-levels of vitamin D can lead to impaired muscle function [4] and increase the risk of falling [5] – both important fracture risk factors. These findings are in line with previous RCTs showing
If a blood test shows very low vitamin D levels, and you are also getting bone pain as a result then higher doses may be prescribed to rapidly improve your vitamin D levels. You may be given a total of approximately 300,000 IU vitamin D, either as weekly or daily doses over 6 to 10 weeks, before you go down to the lower dose taken long term (usually 800IU).
The study authors said they also found that doubling the typical dose of Vitamin D from 400 to 800 IUs could reduce the number of premature infants with extremely low bone density.
If this reflects a causal relation, vitamin D given in high doses may have a negative effect on bone. Given the focus on the need for higher doses of vitamin D [ 15 ] this is an important issue to settle, but so far, most intervention studies have used vitamin D in doses of 800 IU per day or less [ 13 ].
Insufficient Vitamin K2 (and Vitamin D) intake can lead to decreased bone mineral density because osteocalcin is not activated, and thus, Calcium is not directed into the formation of new bone. Not only would this contribute to osteopenia or osteoporosis, but bone fractures and other skeletal issues are more likely to occur.
The role of calcium and vitamin D in bone health in the general population Bess Dawson-Hughes, M.D.
van Amerongen, B.M.; Feron, F. Effect of High-Dose Vitamin D3 Intake on Ambulation, Muscular Pain and Bone Mineral Density in a Woman with Multiple Sclerosis: A 10 …
Abstract. High doses of the active form of vitamin D 3, 1,25-dihydroxyvitamin D 3 [1,25(OH) 2 D 3], prevent diabetes in the NOD mouse but also elicit unwanted calcemic side effects.
Furthermore, it has been shown that high-levels of vitamin D can lead to impaired muscle function [4] and increase the risk of falling [5] – both important fracture risk factors. These findings are in line with previous RCTs showing more falling and increased fracture risk in individuals randomized to high-dose vitamin D [2],[3].

How to Increase Bone Density 13 Steps (with Pictures
Vitamin D supplements and tests NOS UK Charity

Effect of High-Dose Vitamin D3 Intake on Ambulation, Muscular Pain and Bone Mineral Density in a Woman with Multiple Sclerosis: A 10-Year Longitudinal Case Report Barbara M. van Amerongen 1,2,* and François Feron 3 1 Department of Molecular Cell Biology and Immunology, VU University Medical Center, 1017 MB Amsterdam, The Netherlands 2 Department of Cariology Endodontology …
Many lines of evidence suggest that low calcium intake adversely affects bone mineral density. 1 Low calcium intake has been associated with lower bone density in some cross-sectional studies, 4–6 though not all. 7 Interventions to increase calcium intake in postmenopausal women have shown beneficial effects on bone density, 8–10 though in some studies the benefit was small and
Participants who had received the monthly high dose of vitamin D3 had gained an average bone mineral density of 1.15 percent, compared to an average increase of .09 percent in the placebo group. For participants in the high dose vitamin D3 group, improvement in bone density occurred regardless of whether they had a deficiency of the vitamin when they enrolled in the study.
The study authors said they also found that doubling the typical dose of Vitamin D from 400 to 800 IUs could reduce the number of premature infants with extremely low bone density.

Dosage of Vitamin D3 and Bone Strength jamanetwork.com
The benefits of Vitamin D3 with Vitamin K2 and Calcium

The role of calcium and vitamin D in bone health in the general population Bess Dawson-Hughes, M.D.
received placebo or high-dose vitamin D3 (a loading dose of 540,000 IU and starting 1 month after the loading dose five monthly maintenance doses of 90,000 IU).
L. M. Smith, J. C. Gallagher, M. Kaufmann and G. Jones, Effect of increasing doses of vitamin D on bone mineral density and serum N‐terminal telopeptide in elderly women: a randomized controlled trial, Journal of Internal Medicine, , (2018).
This suggests that dietary vitamin D3 supplementation may increase bone health by improving bone material strength and supports the use of vitamin D 3 supplementation, during adolescence, for achieving a higher peak bone mass in adulthood and thereby preventing osteoporosis.
Furthermore, it has been shown that high-levels of vitamin D can lead to impaired muscle function [4] and increase the risk of falling [5] – both important fracture risk factors. These findings are in line with previous RCTs showing more falling and increased fracture risk in individuals randomized to high-dose vitamin D [2],[3].
High doses of vitamin D and calcium can cause problems, such as kidney stones. Limit intake of vitamin A, particularly in the form of retinol. Too much vitamin A can lower bone density.
van Amerongen, B.M.; Feron, F. Effect of High-Dose Vitamin D3 Intake on Ambulation, Muscular Pain and Bone Mineral Density in a Woman with Multiple Sclerosis: A 10 …
bone material strength and supports the use of vitamin D 3 supplementation, during adolescence, for achieving a higher peak bone mass in adulthood and thereby preventing osteoporosis.
Many lines of evidence suggest that low calcium intake adversely affects bone mineral density. 1 Low calcium intake has been associated with lower bone density in some cross-sectional studies, 4–6 though not all. 7 Interventions to increase calcium intake in postmenopausal women have shown beneficial effects on bone density, 8–10 though in some studies the benefit was small and